FRIDAY, Aug. 5, 2022 (HealthDay News) — A history of early menopause is associated with an increased incidence of heart failure and atrial fibrillation (AF), according to a study published online Aug. 4 in the European journal of the heart.
Jean Shin, from the Korea University College of Medicine in Seoul, and colleagues examined the association of premature menopause with the risk of heart failure and AF in 1,401,175 postmenopausal women.
The researchers identified 42,699 (3.0%) and 44,834 (3.2%) new cases of heart failure and AF, respectively, after an average follow-up of 9.1 years. Women with versus those without a history of early menopause had an increased risk of heart failure and AF (hazard ratios, 1.33 and 1.09, respectively). A trend of significantly increased hazard ratios for heart failure and AF was observed in women aged 45-49, 40-44, and under 40 at menopause compared to women aged 50 or over at menopause. The results were reinforced by a series of sensitivity analyses.
“Evidence is accumulating that menopause before age 40 may increase the risk of heart disease later in life,” a co-author said in a statement. “Our study indicates that reproductive history should be routinely considered in addition to traditional risk factors such as smoking when assessing the likelihood of future heart failure and atrial fibrillation.”